Beirut: Rescuers and medics say at least 70 people have died in Syria after toxic gas was dropped on Douma, the last rebel-held town in Eastern Ghouta, reports BBC news.

Syrian state media denied government forces had launched any chemical attack and said rebels in the eastern Ghouta town of Douma were in a state of collapse and spreading false news.

The US State Department said it was monitoring the situation and that Russia should be blamed if chemicals were used.

Reuters could not independently verify reports of a chemical attack.

The Syrian government has recaptured nearly all of eastern Ghouta from rebels in an offensive that began in February, leaving just Douma in the hands of an insurgent group, Jaish al-Islam.

Russian-backed Syrian government forces resumed the assault on Friday afternoon with heavy air strikes after days of calm.

The Syrian Observatory for Human Rights said 11 people had died in Douma as a result of suffocation caused by the smoke from conventional weapons being dropped by the government. It said a total of 70 people suffered breathing difficulties.

Rami Abdulrahman, the Observatory director, said he could not confirm if chemical weapons had been used.

Medical relief organization Syrian American Medical Society (SAMS) said a chlorine bomb hit Douma hospital, killing six people, and a second attack with ‘mixed agents’ including nerve agents had hit a nearby building.

Basel Termanini, the US-based vice president of SAMS, told Reuters the total death toll in the chemical attacks was 35. ‘We are contacting the UN and the US government and the European governments,’ he said by telephone.

The political official of Jaish al-Islam said the chemical attack had killed 100 people.

A US State Department official in a statement said the Syrian government’s history of using chemical weapons against its own people ‘was not in dispute’. ‘Russia ultimately bears responsibility for the brutal targeting of countless Syrians with chemical weapons,’ the official said.

Syrian state news agency SANA said the rebel group in Douma, Jaish al-Islam, was making ‘chemical attack fabrications in an exposed and failed attempt to obstruct advances by the Syrian Arab army,’ citing an official source.

In the face of military defeat, rebel groups in other parts of eastern Ghouta opted to accept safe passage out of the area to the opposition-held territory at the Turkish border.

Several thousand people — fighters and civilians — left Douma for northern Syria in recent days as Jaish al-Islam held talks with Russia over Douma. Jaish al-Islam has insisted on remaining in the town.

The group rejects what it calls President Bashar al-Assad’s policy of forcibly transferring his opponents to areas near the Turkish border.

Rebel-held areas of the Ghouta region were hit in a major chemical attack in 2013.

Last year, a joint inquiry by the UN and the Organization for the Prohibition of Chemical Weapons (OPCW) found the Syrian government was responsible for an April 4, 2017 attack using the banned nerve agent sarin in the opposition-held town of Khan Sheikhoun, killing dozens of people.

The inquiry had previously found that Syrian government forces were responsible for three chlorine gas attacks in 2014 and 2015 and that Islamic State militants used mustard gas.