San Jose: Cuba will not accept any interference from the United States in its internal affairs, President Raul Castro said on Wednesday, warning that meddling would make rapprochement between the two countries ‘meaningless’.

His comments came after U.S. Assistant Secretary of State Roberta Jacobson, the highest-ranking U.S. government official to visit the island in 35 years, held talks with Cuban officials on restoring diplomatic relations. Jacobson also met Cuban dissidents, annoying Cuban officials.

"Everything appears to indicate that the aim is to foment an artificial political opposition via economic, political and communicational means," Castro told a summit in Costa Rica.

Castro said during the visit with American diplomats that Cuba had proposed that it be removed from a blacklist of state sponsors of terrorism, and the return of the U.S. Guantanamo naval base.

The Cuban leader also urged U.S. President Barack Obama to use executive powers to ease a decades-long embargo against Cuba, saying Washington could extend measures like those announced for telecoms to other areas of the economy.

Any U.S. companies would have to reach an agreement with Cuban authorities before doing business on the island.

Castro said Obama's decision to hold a debate in Congress about eliminating the embargo was ‘significant’, adding that he was aware that ending it ‘will be a long and hard road’.

The historic high-level talks between United States and Cuba in Havana are expected to lead to re-establishment of diplomatic ties that were severed by Washington in 1961.